Protocol Components
Duration & Cycling: 4 to 8 Weeks
Morning
Inject BPC-157 + TB-500 (Mixed or Separate)
Systemic or local.
Evening
Inject GHK-Cu (1-2mg) SEPARATELY
Do NOT mix in same syringe. Rotate sites due to sting.
Mechanism of Action
This stack expands on the 'Wolverine' protocol by adding GHK-Cu for genomic and skin-level repair.
1. BPC-157 + TB-500: Handle the deep tissue structural repair (tendons, ligaments, muscles) via angiogenesis and actin mobilization.
2. GHK-Cu (The Remodeler): Adds a third dimension—collagen cross-linking and genomic resetting. GHK-Cu resets the gene expression of damaged cells to a younger state and prevents scar tissue formation by regulating metalloproteinases.
Critical Protocol Note: Dr. Bachmeyer emphasizes that GHK-Cu is often painful and has a different pH than BPC/TB-500. Mixing them in the same syringe can degrade the peptides or cause significant injection site pain. Therefore, this stack requires GHK-Cu to be injected separately, often in a different location (e.g., glute vs belly).
References
- BPC-1572025Emerging Use of BPC-157 in Orthopaedic Sports MedicinePubMed CentralSystematic/narrative review summarizing preclinical musculoskeletal findings and discussing limited human evidence.
- BPC-1572025Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal HealingPubMed CentralNarrative/scoping review focusing on mechanisms, potential applications, and safety concerns in musculoskeletal contexts.
- BPC-1572025Stable Gastric Pentadecapeptide BPC 157 as Therapy After Quadriceps Muscle-to-Bone Detachment to Reattachment in RatsPubMedPreclinical rat study exploring functional recovery after muscle-to-bone injury with BPC-157 therapy.
- TB-500 (Thymosin Beta-4 Fragment)Key FindingsTβ4 accelerates re-epithelializationPubMedIncreased angiogenesis and collagen deposition by 61%.
- TB-500 (Thymosin Beta-4 Fragment)RecentDiabetic endothelial dysfunctionBioMed CentralImproved cell viability and reduced senescence.
- GHK-Cu2018GHK-Cu: The Copper Peptide for Skin and HairPubMed CentralComprehensive review on regenerative and genomic effects.
- GHK-Cu2018Regenerative and Protective Actions of GHK-Cu in Light of the New Gene DataInt J Mol SciDetailed analysis of the Broad Institute genomic connectivity map data.
Used For
Comprehensive Tissue Repair
Scar Reduction
Skin Tightening
Genomic Reset
Important Notes
Injection Sting
GHK-Cu is known to sting; separate injection mitigates reaction.
Research Use OnlyThis information is for educational and research purposes only. Always consult properly licensed professionals.