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Tissue RepairRecovery

TB-500 (Thymosin Beta-4 Fragment)

Promotes cell migration and new blood vessel growth

Overview

TB-500 is a synthetic fragment (residues 17-23) of the naturally occurring Thymosin Beta-4 protein. It is best known for its ability to upregulate actin, a cell building block, allowing cells to migrate rapidly to sites of injury. It promotes angiogenesis (new blood vessels) and reduces inflammation/fibrosis, making it a staple for muscle tears and tendonitis recovery.

Chemical Information

IUPAC Name
N-Acetyl-LKKTETQ
Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-... (Fragment often Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln)
Molecular Mass
4963 Da (Full Tβ4) / ~800-900 Da (Fragment)
Formula
C212H350N56O78S (Full)
TB-500 (Thymosin Beta-4 Fragment) Chemical Structure

Mechanism of Action

Functions primarily as an Actin-Sequestering Peptide. It binds to G-Actin (globular actin), maintaining a pool of ready-to-use actin monomers. When an injury occurs, TB-500 releases this actin to facilitate rapid polymerization into F-Actin filaments. This effectively gives cells the 'legs' they need to migrate (move) quickly to the wound site. Additionally, it stimulates the Akt/eNOS pathway to trigger angiogenesis (growth of new capillaries), ensuring the injured tissue receives the blood flow necessary for repair. It also blocks the TGF-beta pathway, which is responsible for scar tissue formation, leading to 'cleaner' healing.

Potential Research Fields

Muscle TearsTendonitisCardiac RepairCorneal HealingAlopecia

Recent Research

While BPC-157 is often called the 'biochemical engineer' (signaling repair), TB-500 is the 'construction crew' (moving cells to the site). 2024 research continues to validate its role in angiogenesis (growing new blood vessels), with new studies highlighting its potential in cardiac repair post-heart attack. It helps dormant progenitor cells migrate to damaged heart tissue to prevent scarring. Additionally, it is being studied for hair growth, as it stimulates stem cells in the hair follicle bulge.

Bibliography / Scientific References

Related Peptides

Research
BPC-157

Supports tissue repair and recovery in preclinical research

Research
KLOW

4-in-1 Blend (GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg, KPV 10mg) for systemic repair

Peptide Information Guide
Administration Type
Injectable (Subcutaneous)

Injectable administration protocol for research.

Vial Strength
10mg
Reconstitution
Reconstitute with 2ml bacteriostatic water
Dosage Options
0.5 mg (10 units)
Mon-Fri
Standard Protocol: 10mg/2ml (5mg/ml). 3 Month Cycle.
Ramp-Up Protocol
Mon-Fri
Wk 1-2: 0.5mg (10u). Wk 3-4: 0.6mg (12u). Wk 5-8: 0.75mg (15u). Wk 9-12: 1mg (20u). Rest 3mo.
Schedule
Mon-Fri
Timing: One specific day.
Duration
3 Months
Potential Side Effects
Temporary fatigue (repair mode)
lowcommon
Headache (vasodilation)
lowoccasional
Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.