Skin HealthRegeneration

GHK-Cu

Copper tripeptide for genomic reset, skin repair, and wound healing

Overview

GHK-Cu (Copper Tripeptide-1) is a naturally occurring human tripeptide complex renowned for its broad regenerative and genomic effects. Originally isolated from plasma, it acts as a copper-delivery system that declines with age. It is extensively studied for its ability to reset gene expression to a 'youthful' state, accelerate wound healing, and stimulate collagen production. Supplied as a lyophilized blue powder for research.

Chemical Information

IUPAC Name

Copper(II)-Glycyl-L-histidyl-L-lysine

Sequence

Gly-His-Lys (Cu2+ Complex)

Molecular Mass

404.9 Da

Formula

C14H22CuN6O4

Mechanism of Action

Functions as a potent copper-delivery system and genomic modulator. Its high affinity for copper (Cu2+) allows it to activate critical copper-dependent enzymes like Lysyl Oxidase, which is essential for the cross-linking and maturation of collagen and elastin fibers. Crucially, transcriptomic studies reveal it acts as a 'master switch' for gene expression, resetting over 4,000 genes (approx. 30% of the genome) to a healthier, younger state. This includes the upregulation of DNA repair pathways and the downregulation of pro-inflammatory cytokines (TNF-α, IL-6) and metastatic genes. It also modulates Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs), preventing scar formation while promoting organized tissue remodeling.

Potential Research Fields

Genomic ReprogrammingWound HealingSkin RejuvenationLung FibrosisDNA Repair

Recent Research

Recent research (2024–2025) has elevated GHK-Cu from a cosmetic ingredient to a 'genomic stabilizer' with systemic potential. Studies utilizing the Broad Institute's Connectivity Map continue to confirm its ability to reverse the transcriptional signature of aging—specifically suppressing genes associated with metastasis (cancer spread) and inflammation while upregulating DNA repair pathways. New findings in 2024 highlight its potential in lung fibrosis and COPD, where GHK-Cu administration significantly reduced inflammatory cell infiltration and collagen deposition in alveolar tissue. Additionally, neurobiology research is investigating its role in protecting spinal cord tissue from oxidative damage by maintaining mitochondrial integrity.

Bibliography / Scientific References

[1]GHK-Cu: The Copper Peptide for Skin and Hair
PubMed Central • 2018 - Comprehensive review on regenerative and genomic effects.
[2]Regenerative and Protective Actions of GHK-Cu in Light of the New Gene Data
Int J Mol Sci • 2018 - Detailed analysis of the Broad Institute genomic connectivity map data.

Related Peptides

Research

GLOW (Blend)

3-in-1 Blend (GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg) for skin and tissue repair

Peptide Information Guide

Administration Type

Injectable (Subcutaneous)

Injectable administration protocol for research.

Vial Strength

50mg100mg

Reconstitution

Reconstitute with 3ml bacteriostatic water

Dosage Options

1–2 mg

Daily

Standard systemic dose for anti-aging/repair

Schedule

1x daily

Timing: One specific day.

Duration

According to the Doctor

Potential Side Effects

Injection site pain (sting)

moderatecommon

Nausea (if zinc deficient)

lowrare

Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.