Cognitive HealthNootropics
Semax
ACTH-derived neuropeptide for cognition and stroke recovery
Overview
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from a fragment of ACTH. Engineered for stability and neurotrophic activity, it lacks hormonal side effects. It is extensively researched for cognitive enhancement, memory improvement, and neuroprotection, particularly in the context of ischemic stroke and oxidative stress.
Chemical Information
IUPAC Name
Met-Glu-His-Phe-Pro-Gly-Pro
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Mass
872.9 Da
Formula
C37H51N9O10S
Mechanism of Action
Functions as a transcriptional regulator and BDNF mimetic. Unlike standard stimulants that just dump neurotransmitters, Semax alters the expression of genes related to the immune system and neuroplasticity. Key mechanisms include: 1. BDNF Upregulation: Rapidly increases Brain-Derived Neurotrophic Factor and TrkB signaling in the hippocampus. 2. Transcriptional Control: Modulates gene networks (chemokines, immunoglobulins) to suppress neuroinflammation during ischemia. 3. Neurotransmitter Balance: Increases the turnover of dopamine and serotonin for improved focus and mood. 4. Melanocortin Signaling: Interacts with MC3R/MC4R receptors to modulate attention and autonomic balance.
Potential Research Fields
Stroke RecoveryCognitive EnhancementADHDNeuroprotectionHypoxia
Recent Research
Research consistently positions Semax as a unique 'genomic modulator' rather than just a stimulant. Pivotal studies (PMC3987924) revealed that within hours of administration, Semax alters the expression of hundreds of genes involved in the immune response and vascular regulation, specifically downregulating pro-inflammatory cytokines during ischemia (oxygen deprivation). This makes it a primary candidate for stroke recovery, where it helps save neurons in the 'penumbra' (the area surrounding an injury). Cognitive studies confirm it enhances BDNF levels, facilitating Long-Term Potentiation (LTP)—the biological basis of learning and memory formation.
Bibliography / Scientific References
- [1]Transcriptome alterations in ischemic brainBMC Genomics • 2014 (Seminal) - Semax affects immune and vascular gene expression.
- [2]Semax in stroke rehabilitationGenes • 2020 - Clinical utility in suppressing inflammatory genes.
Related Peptides
Peptide Information Guide
Administration Type
Injectable (Subcutaneous)Injectable administration protocol for research.
Vial Strength
11mg
Reconstitution
Reconstitute with 3ml bacteriostatic water
Dosage Options
0.4 mg (10 units)
Daily
Protocol for 11mg vial reconstituted w/ 3ml water (conc ~3.7mg/ml)
Schedule
1x daily
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
Mild irritation
lowoccasional
Excitement/Insomnia
lowrare (dose-dependent)
Research Use Only
This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.