Cognitive HealthNootropics

Cerebrolysin

Neurotrophic peptide mixture for neuroprotection and cognitive research

Overview

Cerebrolysin is a pharmacologically active peptide and amino acid complex derived from enzymatic hydrolysis of porcine brain proteins. This low-molecular-weight neurotrophic mixture is designed to mimic the activity of endogenous neurotrophic factors (BDNF, GDNF), supporting neuronal survival, synaptic repair, and neuroplasticity. Extensively investigated in models of ischemic stroke, TBI, and neurodegeneration.

Chemical Information

IUPAC Name

Porcine Brain Peptide Hydrolysate

Sequence

Complex Peptide Mixture (No single sequence)

Molecular Mass

< 10 kDa (Mixture)

Formula

Complex Mixture

Chemical Structure not available

Mechanism of Action

Functions as a broad-spectrum 'multimodal' neuropeptide complex that mimics the biological action of Brain-Derived Neurotrophic Factor (BDNF) and Glial Cell Line-Derived Neurotrophic Factor (GDNF). Mechanistically, it crosses the blood-brain barrier to activate the PI3K/Akt and MAPK/ERK intracellular signaling pathways. This activation inhibits neuronal apoptosis (stopping cell death cascades), reduces excitotoxicity (calming overactive glutamate receptors), and lowers oxidative stress. Uniquely, it stimulates neurogenesis (birth of new neurons) and synaptogenesis (formation of new connections) in the hippocampus, providing a structural basis for restoring cognitive function and motor skills after injury.

Potential Research Fields

Ischemic StrokeTraumatic Brain Injury (TBI)Alzheimer’s DiseaseVascular DementiaAnxiety & Mood

Recent Research

Current research (2024–2025) has expanded the scope of Cerebrolysin from acute stroke care to chronic neuropsychiatric resilience. New evidence suggests it modulates the 'gut-brain axis' and repairs neural circuits involved in emotional regulation, showing promise for treating post-injury anxiety and treatment-resistant depression. In the realm of dementia, studies are validating its use in 'vascular cognitive impairment,' where it appears to stabilize microvascular function and improve executive control. Preclinical trials are also exploring its synergy with rehabilitation, showing that Cerebrolysin 'opens a window of neuroplasticity' that makes physical therapy significantly more effective.

Bibliography / Scientific References

[1]Cerebrolysin and recovery after stroke
Cochrane Library • 2023 - Major review confirming motor recovery benefits.
[2]Neuroprotective effects in Traumatic Brain Injury
Frontiers in Neurology • 2024 - Study on reduced lesion volume and improved cognitive outcomes.

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Peptide Information Guide

Administration Type

Intramuscular Injection

Injectable administration protocol for research.

Vial Strength

60mg

Reconstitution

Reconstitute with 3ml bacteriostatic water

Dosage Options

60 mg (1 Vial)

Every other day (EOD)

Standard intramuscular protocol for neuroprotection

Schedule

1 Day ON / 1 Day OFF

Timing: One specific day.

Duration

According to the Doctor

Potential Side Effects

Mild injection site pain

lowcommon

Transient sensation of heat

lowoccasional

Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.