Cognitive HealthNootropics
Selank
Synthetic neuropeptide for anxiety, memory, and BDNF upregulation
Overview
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from Tuftsin (an IgG immune fragment). It acts as a stable anxiolytic and nootropic that modulates the nervous and immune systems. Unlike benzodiazepines, it reduces anxiety without sedation or addiction, while simultaneously improving memory and cognitive function via BDNF expression.
Chemical Information
IUPAC Name
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Mass
751.9 Da
Formula
C33H57N11O9
Mechanism of Action
Functions as a regulatory neuropeptide with a unique multi-modal mechanism. 1. BDNF Upregulation: It significantly increases the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, promoting neuroplasticity and memory formation. 2. GABAergic Modulation: It acts as an allosteric modulator of the GABA-A receptor, enhancing the brain's natural inhibitory (calming) system to reduce anxiety without the sedation associated with drugs like Xanax. 3. Neuro-Immune Crosstalk: Derived from an immune peptide (Tuftsin), it modulates interferon and cytokine gene expression, stabilizing the immune response to stress. 4. Monoamine Regulation: It optimizes serotonin and dopamine turnover, improving mood and focus.
Potential Research Fields
Anxiety (Generalized)Cognitive EnhancementAlcohol WithdrawalNeuroinflammationDepression
Recent Research
Research focuses on Selank as a 'smart anxiolytic.' Unlike traditional anxiety medications that dampen brain activity (causing brain fog), Selank modulates the GABA system while simultaneously increasing BDNF, effectively calming the mind while sharpening focus. 2019 studies on ethanol exposure demonstrated its neuroprotective capacity, showing it could preserve memory and cognitive function even under toxic stress. Current genomic research highlights its ability to alter the expression of inflammation-related genes, suggesting it treats the 'inflammatory root' of anxiety and stress disorders.
Bibliography / Scientific References
- [1]Selank regulates BDNF expressionResearchGate • 2012 (Key) - Confirmed BDNF upregulation in hippocampus.
- [2]Selank in alcohol withdrawalPubMed • 2019 - Prevented memory impairment induced by ethanol.
Related Peptides
Peptide Information Guide
Administration Type
Injectable (Subcutaneous) / IntranasalInjectable administration protocol for research.
Vial Strength
11mg
Reconstitution
Reconstitute with 2ml bacteriostatic water
Dosage Options
0.3 mg (5 units)
Daily
Protocol for 11mg vial reconstituted w/ 2ml water
Schedule
1x daily
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
None significant (non-sedating)
lowrare
Injection site mild irritation
lowoccasional
Research Use Only
This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.