Protocol Components
Duration & Cycling: 3 to 6 Months
Morning (Fasted)
Inject Tesamorelin (1mg) + Ipamorelin (100mcg)
Wait 30-60 mins before eating.
Before Bed (Optional)
Ipamorelin (100mcg) only
For sleep support.
Mechanism of Action
This stack is the specialist for 'central adiposity'.
1. Tesamorelin: A GHRH analogue unique in its FDA approval for reducing visceral fat in HIV patients. Unlike other GHRHs, it has a specific lipolytic preference for the adipose tissue surrounding organs.
2. Ipamorelin: provides the initiation pulse for Growth Hormone without spiking hunger (ghrelin) or stress hormones (cortisol).
Synergy: Tesamorelin 'unlocks' the fat cells in the midsection, while Ipamorelin ensures the Growth Hormone baseline is high enough to oxidize that liberated fat for energy.
References
- Tesamorelin2019Tesamorelin reduces liver fat in NAFLDThe Lancet HIVClinical trial showing significant reduction in hepatic adipose tissue.
- Tesamorelin2012Effects on cognition in Mild Cognitive ImpairmentArch NeurolImproved executive function and verbal memory in older adults.
- Ipamorelin1998 (Pivotal)Selectivity of IpamorelinEur J EndocrinolDemonstrated GH release without ACTH/Cortisol spikes.
- Ipamorelin2001Ipamorelin in bone growthGrowth Horm IGF ResIncreased bone mineral density in adult rats.
Used For
Visceral Fat Reduction
Improved Lipid Profile
Defined Abs/Midsection
Cardiovascular Risk Reduction
Important Notes
Water Retention
Mild fluid retention possible initially with Tesamorelin.
Research Use OnlyThis information is for educational and research purposes only. Always consult properly licensed professionals.