Muscle GrowthHormone Optimization
Ipamorelin
Selective, 'clean' GH secretagogue (No cortisol/prolactin)
Overview
Ipamorelin is a third-generation synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2). It is distinguished as the 'cleanest' Growth Hormone Secretagogue because it stimulates GH release via the ghrelin receptor without causing the release of stress hormones (cortisol) or prolactin. This selectivity makes it the preferred choice for anti-aging and long-term use.
Chemical Information
IUPAC Name
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular Mass
711.86 Da
Formula
C38H49N9O5
Mechanism of Action
Functions as a highly selective agonist of the Ghrelin Receptor (GHS-R1a) in the pituitary gland. Like GHRP-6, it triggers a pulse of Growth Hormone. However, unlike earlier generations, Ipamorelin does not activate the receptors for ACTH (cortisol precursor) or Prolactin. This means it boosts GH levels for repair and fat loss without putting the body into a 'stress state' or causing water retention/mood swings associated with cortisol. It promotes a natural, pulsatile release that mimics the body's youth physiology.
Potential Research Fields
Anti-AgingBone DensityGut Motility (Post-Op ileus)Muscle RecoverySarcopenia
Recent Research
While older peptides like GHRP-6 and GHRP-2 are effective, they come with the 'baggage' of hunger and stress hormone spikes. Ipamorelin represents the 'refined' evolution of these compounds. 2024 literature reinforces its status as the safest secretagogue for long-term use in regenerative medicine. Recent studies have expanded its scope to include gastrointestinal recovery, showing it can restart gut motility (post-operative ileus) faster than standard care, while simultaneously promoting bone density accrual in osteopenic models.
Bibliography / Scientific References
- [1]Selectivity of IpamorelinEur J Endocrinol • 1998 (Pivotal) - Demonstrated GH release without ACTH/Cortisol spikes.
- [2]Ipamorelin in bone growthGrowth Horm IGF Res • 2001 - Increased bone mineral density in adult rats.
Related Peptides
Peptide Information Guide
Administration Type
Injectable (Subcutaneous)Injectable administration protocol for research.
Vial Strength
10mg
Reconstitution
Reconstitute with 2ml bacteriostatic water
Dosage Options
0.5 mg (10 units)
Daily (Mon-Fri)
Protocol for 10mg vial/2ml water. (Conc: 5mg/ml. 10 units = 0.1ml = 0.5mg). Take on empty stomach.
Schedule
5 days/week
Timing: One specific day.
Duration
3 Months
Potential Side Effects
Headache (mild)
lowrare
Research Use Only
This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.