Protocol Components
Duration & Cycling: 3 to 6 Months
Nightly (Mon-Fri)
Inject Blend (100mcg CJC / 100mcg Ipa)
Take on an empty stomach, 30 mins before bed, for max GH pulse during sleep.
Mechanism of Action
This stack leverages the concept of 'Dual-Pathway Stimulation' to maximize endogenous Growth Hormone (GH) production while maintaining physiological safety.
1. CJC-1295 No DAC (The Amplifier): Acts on the GHRH receptor in the pituitary gland. It increases the *volume* of GH released per pulse but cannot initiate the pulse effectively on its own.
2. Ipamorelin (The Initiator): Acts on the Ghrelin receptor (GHSR-1a). It creates a sharp *initiation* signal for a GH pulse and suppresses somatostatin (the hormone that blocks GH).
Synergy: When administered together, they create a non-linear 'multiplying effect.' Ipamorelin starts the pulse and removes the 'brake' (somatostatin), allowing CJC-1295 to maximize the 'gas' (GHRH). Clinical data suggests this combination releases 5x more GH than either agent alone. Furthermore, because both are selective, they do not trigger cortisol (stress) or prolactin, avoiding the water retention and moodiness associated with older generation peptides.
References
- CJC-1295 No DAC2006Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analogPubMedFoundational study distinguishing pulsatile vs continuous GH release dynamics.
- CJC-1295 No DAC2006Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsPubMedClinical trial data on pharmacokinetics and safety.
- Ipamorelin1998 (Pivotal)Selectivity of IpamorelinEur J EndocrinolDemonstrated GH release without ACTH/Cortisol spikes.
- Ipamorelin2001Ipamorelin in bone growthGrowth Horm IGF ResIncreased bone mineral density in adult rats.
Used For
Deep Sleep Restoration
Increased Lean Muscle
Fat Loss
Improved Skin Elasticity
Important Notes
Head Rush
Temporary warm flush immediately after injection (vasodilation).
Vivid Dreams
Sign of deep REM sleep activation.
Research Use OnlyThis information is for educational and research purposes only. Always consult properly licensed professionals.