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Tissue RepairRecovery

KLOW

4-in-1 Blend (GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg, KPV 10mg) for systemic repair

Overview

KLOW is a synergistic multi-peptide formulation designed to target the four pillars of tissue regeneration: genomic remodeling (GHK-Cu), cell migration/actin regulation (TB-500), structural repair/angiogenesis (BPC-157), and inflammation control (KPV). This 'entourage effect' formulation is studied for its ability to accelerate healing, improve skin density, resolve gut inflammation, and recover muscle tissue simultaneously.

Chemical Information

IUPAC Name
Multi-Peptide Blend (GHK-Cu 50mg, TB-500 10mg, BPC-157 10mg, KPV 10mg)
Sequence
Combination of 4 sequences
Molecular Mass
Mixture (N/A)
Formula
Mixture (N/A)
Chemical Structure not available

Mechanism of Action

Functions as a comprehensive 'quad-action' regenerative signal complex. 1. GHK-Cu: Acts as a copper-delivery system and genomic modulator, activating lysyl oxidase to cross-link collagen and elastin while resetting aging genes. 2. TB-500: Binds to actin monomers (G-actin), regulating cytoskeletal flexibility to drive rapid cell migration (re-epithelialization) and new blood vessel growth. 3. BPC-157: Stimulates the VEGF/NO axis, promoting vascular maturation and the structural organization of tendons and ligaments. 4. KPV: Targets the PepT1 transporter to enter immune cells and inhibit NF-κB, dampening pro-inflammatory cytokines (IL-1β, TNF-α) without suppressing the immune system. Together, they cover the full healing cascade: Inflammation Control → Cell Recruitment → Vascularization → Tissue Remodeling.

Potential Research Fields

Systemic RegenerationDermal RejuvenationGut Health (IBD)Muscle RecoveryInflammaging

Recent Research

Recent research (2024–2025) validates the 'combinatorial approach' to regenerative medicine seen in the KLOW blend. While individual peptides target specific pathways, this blend mimics the body's natural 'healing milieu' by addressing multiple stages of repair simultaneously. Studies in Frontiers in Pharmacology (TB-500) and MDPI Biomolecules* (GHK-Cu) suggest that simultaneous modulation of inflammation (via KPV/BPC-157) and matrix synthesis (via GHK-Cu/TB-500) significantly accelerates wound closure times and reduces scar tissue compared to monotherapy. This blend is specifically being investigated for 'systemic rejuvenation,' where the goal is a holistic reduction in inflammaging (aging driven by chronic inflammation) across skin, gut, and musculoskeletal systems.

Bibliography / Scientific References

Related Peptides

Research
BPC-157

Supports tissue repair and recovery in preclinical research

Research
TB-500 (Thymosin Beta-4 Fragment)

Promotes cell migration and new blood vessel growth

Peptide Information Guide
Administration Type
Injectable (Subcutaneous)

Injectable administration protocol for research.

Vial Strength
80mg
Reconstitution
Reconstitute with 3ml bacteriostatic water
Dosage Options
5 units (approx 1.5mg)
Daily
Standard maintenance protocol based on 80mg/3ml concentration
Schedule
1x daily
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
Injection site sensitivity
moderatecommon
Copper sensation (metallic taste)
lowrare
Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.