Muscle GrowthHormone Optimization
GHRP-6
Ghrelin-mimetic for GH release and cardioprotection
Overview
GHRP-6 (Growth Hormone Releasing Peptide-6) is a potent synthetic hexapeptide that stimulates Growth Hormone (GH) release by mimicking the hunger hormone Ghrelin. It binds to the GHSR-1a receptor, triggering a strong pulse of GH. Beyond growth, it is extensively studied for its ability to reduce cardiac fibrosis (scarring) after heart attacks and protect neurons from ischemic damage.
Chemical Information
IUPAC Name
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular Mass
873.0 Da
Formula
C46H56N12O6
Mechanism of Action
Functions as a selective agonist of the Ghrelin Receptor (GHSR-1a) found in the pituitary gland and hypothalamus. Unlike GHRH analogues (like CJC-1295) that amplify the *size* of a GH pulse, GHRP-6 initiates the *timing* of the pulse. This pathway is distinct and synergistic: when combined with a GHRH, it creates a massive 'multiplying effect' on GH release. Additionally, GHRP-6 has direct receptors on heart tissue (CD36), where it mediates distinct cardioprotective effects, specifically reducing collagen deposition (fibrosis) and preventing cell death during ischemia (low oxygen).
Potential Research Fields
Cardioprotection (Fibrosis)SarcopeniaAppetite StimulationGastric MotilityIschemia
Recent Research
Research in 2024 has distinguished GHRP-6 from newer secretagogues (like Ipamorelin) by focusing on its unique 'off-target' benefits for the heart. A major study in *Frontiers in Pharmacology* (2024) highlighted GHRP-6's ability to block cardiac fibrosis (scar tissue formation) in hearts damaged by chemotherapy (doxorubicin). This anti-fibrotic action appears largely independent of GH release, acting instead through CD36 receptors on fibroblasts. Furthermore, because it strongly mimics ghrelin, it remains a primary candidate for treating cachexia (wasting syndrome) in cancer and elderly patients, where its ability to simultaneously stimulate appetite and build muscle provides a dual therapeutic advantage.
Bibliography / Scientific References
- [1]GHRP-6 reduces cardiac fibrosisFrontiers in Pharmacology • 2024 - Demonstrated protective effects against chemotherapy-induced heart damage.
- [2]Ghrelin mimetics in cachexiaPMC • 2017 - Review of efficacy in reversing muscle wasting.
Related Peptides
Peptide Information Guide
Administration Type
Injectable (Subcutaneous)Injectable administration protocol for research.
Vial Strength
10mg
Reconstitution
Reconstitute with 2ml bacteriostatic water
Dosage Options
0.5 mg (10 units)
Mon-Fri
Protocol for 10mg vial reconstituted w/ 2ml water
Schedule
Mon-Fri
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
Extreme Hunger (Ghrelin effect)
highvery common
Water retention
moderatedose-dependent
Research Use Only
This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.