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Weight LossMetabolic Health

AOD-9604

Lipolytic peptide fragment for fat loss and cartilage repair

Overview

AOD-9604 is a synthetic peptide fragment (Tyr-hGH177-191) derived from the C-terminus of human Growth Hormone. It is designed to retain the lipolytic (fat-burning) properties of GH without the anabolic or glycemic side effects (no IGF-1 increase). Research highlights its dual role in stimulating fat breakdown and promoting cartilage regeneration in osteoarthritis models.

Chemical Information

IUPAC Name
Tyrosyl-hGH Fragment 177-191
Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular Mass
1815.1 Da
Formula
C78H123N23O23S2
AOD-9604 Chemical Structure

Mechanism of Action

Functions as a specific lipolytic fragment of Human Growth Hormone (hGH). Unlike full-length GH, it does not bind to the primary GH receptor (GHR) to trigger IGF-1 release, avoiding anabolic growth or insulin resistance. Instead, it acts directly on adipose tissue by upregulating beta-3 adrenergic receptors (β3-AR). This triggers the breakdown of stored triglycerides (lipolysis) while simultaneously inhibiting the enzymatic pathway for new fat formation (lipogenesis). Additionally, in connective tissue, it stimulates chondrocyte (cartilage cell) proliferation and collagen production, providing a benefit for joint repair.

Potential Research Fields

ObesityOsteoarthritisMetabolic SyndromeCartilage RepairLipid Metabolism

Recent Research

Recent research (2024–2025) has expanded AOD-9604's application from a simple 'fat burner' to a key agent in regenerative orthopedics. While its ability to reduce visceral fat without affecting blood sugar remains confirmed, new studies focus on its role in osteoarthritis. Research indicates that intra-articular administration (often combined with Hyaluronic Acid) significantly promotes the regeneration of hyaline cartilage and reduces joint inflammation. This 'dual-metabolic' action—reducing the weight load on joints via fat loss while directly repairing the cartilage tissue—positions it as a unique therapeutic candidate for obesity-related musculoskeletal disorders.

Bibliography / Scientific References

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Peptide Information Guide
Administration Type
Injectable (Subcutaneous)

Injectable administration protocol for research.

Vial Strength
5mg
Reconstitution
Reconstitute with 1ml bacteriostatic water
Dosage Options
0.5 mg (10 units)
Mon-Fri
Protocol based on 5mg/1ml concentration
Schedule
5 days/week
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
Injection site pain
lowcommon
Headache
lowrare
Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.