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Sexual HealthWellness

PT-141 (Bremelanotide)

Central nervous system activator for libido and arousal (Men & Women)

Overview

PT-141 (Bremelanotide) is a synthetic peptide originally developed for tanning (Melanotan II derivative) but found to profoundly stimulate sexual arousal. Unlike Viagra (which fixes blood flow), PT-141 fixes the 'signal' in the brain. It is FDA-approved for Hypoactive Sexual Desire Disorder (HSDD) in women and is used off-label for Erectile Dysfunction in men, particularly those who don't respond to standard pills.

Chemical Information

IUPAC Name
Cyclo-[Nle4, Asp5, D-Phe7, Lys10]-alpha-MSH-(4-10)
Sequence
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH (Cyclic)
Molecular Mass
1025.2 Da
Formula
C50H68N14O10
PT-141 (Bremelanotide) Chemical Structure

Mechanism of Action

Functions as a non-selective Melanocortin Receptor Agonist. It targets MC3R and MC4R receptors in the hypothalamus (the brain's control center). By activating these receptors, it triggers the release of dopamine, the neurotransmitter responsible for motivation and desire. This creates a 'central' arousal response—meaning the desire starts in the brain and travels down, rather than just mechanically dilating blood vessels like PDE-5 inhibitors (Cialis/Viagra). This makes it unique in that it treats the *lack of desire* (libido), not just the mechanical failure.

Potential Research Fields

Hypoactive Sexual Desire Disorder (HSDD)Erectile Dysfunction (ED)Dopaminergic SignalingMelanocortin System

Recent Research

PT-141 stands alone as the only FDA-approved peptide for increasing sexual desire (libido) rather than just performance. Research published in 2022 (Journal of Women's Health) confirmed its efficacy in premenopausal women with Hypoactive Sexual Desire Disorder (HSDD), showing that it re-sensitizes the brain's reward pathways to sexual cues. In men, 2024 studies are exploring its use in 'psychogenic ED' (performance anxiety), where standard drugs like Viagra fail because the issue is mental/neurochemical, not vascular. It bypasses the anxiety loop by directly stimulating the hypothalamic arousal center.

Bibliography / Scientific References

Related Peptides

No related peptides found.

Peptide Information Guide
Administration Type
Injectable (Subcutaneous)

Injectable administration protocol for research.

Vial Strength
10mg
Reconstitution
Reconstitute with 1ml bacteriostatic water
Dosage Options
1 mg (10 units)
As needed
Protocol for 10mg/1ml. Inject 45 mins before activity. Max 1 dose/24hr. Max 8 doses/month.
Schedule
As needed (45 mins prior)
Timing: One specific day.
Duration
Max 8x/Month
Potential Side Effects
Nausea (transient)
moderatevery common (lasts ~1 hr)
Flushing/Redness
lowcommon
Research Use Only

This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.