SleepStress Management
DSIP (Delta Sleep-Inducing Peptide)
Neuropeptide for deep sleep promotion and stress modulation
Overview
DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood during slow-wave sleep. It is studied for its ability to normalize sleep architecture, regulate stress hormones (ACTH), and provide neuroprotection against oxidative stress.
Chemical Information
IUPAC Name
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular Mass
848.8 Da
Formula
C35H48N10O15
Mechanism of Action
Functions as a neuromodulator of the Delta-rhythm (slow-wave sleep). While its specific receptor remains elusive, it acts on the hypothalamus to stabilize the circadian rhythm and suppress the release of ACTH (the precursor to cortisol), effectively dampening the body's stress response. It also modulates NMDA glutamate receptors to prevent excitotoxicity and boosts mitochondrial antioxidant enzymes, protecting neurons from oxidative damage during sleep deprivation.
Potential Research Fields
InsomniaStress (ACTH Regulation)Stroke RecoveryCircadian RhythmsEpilepsy
Recent Research
Research in 2024 is revisiting DSIP not just as a sleep aid, but as a 'stress resilience' peptide. While it remains a potent promoter of Deep Slow Wave Sleep (SWS)—the phase where physical repair occurs—new studies emphasize its ability to regulate the HPA axis (Hypothalamus-Pituitary-Adrenal). By blunting the release of ACTH and cortisol in response to stress, it prevents the 'hyperarousal' that causes insomnia. Furthermore, neurobiology research highlights its role in protecting mitochondria from oxidative stress, suggesting it helps the brain 'clean house' during sleep, reducing the accumulation of toxins associated with neurodegeneration.
Bibliography / Scientific References
- [1]DSIP improves sleep in insomniaEur Neurol • 1992 - Clinical trial showing reduced latency and improved efficiency.
- [2]Neuroprotective effects in strokeMolecules • 2021 - Demonstrated motor recovery and antioxidant effects.
Related Peptides
No related peptides found.
Peptide Information Guide
Administration Type
Injectable (Subcutaneous)Injectable administration protocol for research.
Vial Strength
5mg15mg
Reconstitution
Reconstitute with 2ml (5mg vial) or 3ml (15mg vial) bacteriostatic water
Dosage Options
0.125 mg (5 units)
Daily (Tapering)
Protocol for 5mg/2ml: Daily week 1, then reduce 1 day/week. 30 min before bed.
0.15 mg (2-3 units)
3-4x Week
Protocol for 15mg/3ml: 30 min before bed.
Schedule
Variable (See Options)
Timing: One specific day.
Duration
According to the Doctor
Potential Side Effects
Mild headache
lowoccasional
Vivid dreams
lowcommon
Research Use Only
This information is for research purposes only. Always consult with a healthcare professional before starting any peptide protocol. Individual responses may vary, and proper medical supervision is recommended for all peptide therapies.